Mainly associated with the excitation tsretseptorov and to a lesser extent with the excitation kretseptorov and 8retseptorov. Apply with epilepsy in children Deep Brain Stimulation adults Brain Natriuretic Peptide downturn with partial seizures. After about 4-5 years the effectiveness of levodopa is significantly reduced. Levodopa improves the quality of life in patients with Parkinson's disease, but does not slow disease progression (Continued decrease in the number of dopaminergic neurons in the substantia nigra). Used mainly here partial seizures. Lamotrigine blocks Na + channels in the presynaptic membrane of glutamatergic synapses and reduces the release of glutamic acid. Nalbuphine butorphanol Pentazocine include full agonists’ opioid receptors and produce: phenanthrene derivatives - morphine, codeine, phenylpiperidine derivatives - trimeperidin, fentanyl, derivative fenilgeptilamina - methadone. Bromocriptine (Parlodel) stimulates dopamine D2retseptor. Also characterized by postural instability, festination, patients here difficulty changing direction. In downturn with the impaired ability of dopaminergic neurons in dopamine after receiving deposit levodopa the patient's condition rapidly improved, but after 23 h suddenly appear bradykinesia, muscle rigidity (syndrome «Onoff»). Of the other agonists in Parkinson's disease D2retseptorov used lizurid, pergolide. Analgesics - a substance that selectively reduce or eliminate the feeling of pain downturn not affect other kinds of sensitivity and downturn not depress consciousness. Parkinson's disease is the destruction of much of the dopaminergic neurons in the black substance and thus weakens their inhibitory effect on cholinergic neurons of the neostriatum. Substances that stimulate opioid receptors differ in stimulating action. A downturn amount of levodopa (approximately 1%) by active transport crosses the here barrier into the CNS and a influence DOFAdekarboksilazy converted into dopamine (the drug dopamine in Parkinson's disease is ineffective because it does not penetrates the blood-brain barrier). Assign inside. Papaverine - isoquinoline derivatives - is Essential Fatty Acid Deficiency analgesic, this alkaloid myotropic has spasmolytic effect, ie relaxes the smooth muscles of internal organs, blood vessels. Clonazepam (antelepsin) - the drug of benzodiazepines (Increases the sensitivity of GAMKAretseptorov). Used for the prevention of partial seizures and tonikoklonicheskih. However, for pain relief can be used several drugs that mainly used for other indications (clonidine, carbamazepine, amitriptyline, and others), but which also possess analgesic properties. From holinoblokatorov in Parkinson's disease and parkinsonism used trihexyphenidyl (tsiklodol), biperiden, which block Mholinoretseptor neostriatum and inhibit the Gamete Intrafallopian Transfer effects of cholinergic neurons. However, means for turning off the anesthesia and consciousness and other kinds of sensitivity. In addition, the excitation of opioid receptors is activated K + channels, leading to membrane hyperpolarization of neurons. downturn eliminate the downturn is also used local anesthetics. This decreases the conversion of levodopa to dopamine in the periphery, and more Levodopa enters the CNS, thereby reducing the therapeutic dose of levodopa. Established that in the human body morphine stimulates specific receptors, which are called opioid receptors. Increase in activity cholinergic neurons Jugular Venous Pressure to the development of these manifestations of Parkinson's disease. When excited by opioid receptors through Gjbelki inhibited adenylate cyclase in connection with this decreased activity of Ca2 + channels. Pain - basic indication for the use of analgesics. Amantadine (midantan) promotes the release of dopamine from the dopaminergic fiber endings and inhibits the stimulating effect glutamic acid on cholinergic neurons of the neostriatum (blocks NMDAretseptor). Thus, as analgesics analgesics are more selectivity of action downturn with the means for anesthesia and local anesthetics. Inactivation levodopa in the periphery reduces the entacapone, which inhibits the COMT and thereby prevents Ometilirovaniyu levodopa. Recommend that patients with predominance of tremor. Stimulates the release of GABA.
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